The preclinical imaging center (PIC) consolidates several research groups devoted to development of novel functional and molecular imaging methods. PIC possesses state-of-the-art infrastructure for in vivo imaging in mice and rats, including an independent animal housing facility located within the same hygiene area. Our multi-modality imaging capacities include advanced functional magnetic resonance (fMRI), multi-spectral optoacoustic tomography (MSOT) scanners, fluorescence and multi-photon microscopes, functional ultrasound and more. Some of the instruments and core methodologies were invented and built in our center thus have no analogues worldwide. The facilities are fully equipped with advanced animal surgical tools, anesthesia systems, physiology monitoring suites, high-end computational resources, and other key equipment for small animal imaging research. Our partners primarily originate from the biomedical research community within USZ, UZH and ETH Zürich and, to some extent, from academic and research institutions outside Zurich as well as industrial partners. As part of its research framework, PIC provides access to high end 7T and 9.4T small-animal MRI scanners equipped with cryocoils.